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Quantification of Load Dependent Brain Activity in Parametric N-Back Working Memory Tasks using Pseudo-continuous Arterial Spin Labeling (pCASL) Perfusion Imaging
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ABSTRACT
Quantification of Load Dependent Brain Activity in Parametric N-Back Working Memory Tasks using Pseudo-continuous Arterial Spin Labeling (pCASL) Perfusion Imaging
KEYWORD
N-back working memory , cerebral blood flow , load ef fects , pseudo-continuous arterial spin labeling (pCASL)
참고문헌
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  • [ Table 1. ]  Behavior data of the four working memory task loads
    Behavior data of the four working memory task loads
  • [ Table 2. ]  Quantitative CBF of the whole brain
    Quantitative CBF of the whole brain
  • [ Figure 1. ]  Paired t-maps between the three active working memory task conditions and the 0 back baseline vigilance task condition based on quantified CBF. p < 0.05 corrected. ‘L’ denotes the left hemisphere of the brain and ‘R’ denotes the right hemisphere.
    Paired t-maps between the three active working memory task conditions and the 0 back baseline vigilance task condition based on quantified CBF. p < 0.05 corrected. ‘L’ denotes the left hemisphere of the brain and ‘R’ denotes the right hemisphere.
  • [ Figure 2. ]  Trend t-maps across the four working memory conditions based on quantified CBF. p < 0.05 corrected. ‘L’ denotes the left hemisphere of the brain and ‘R’ denotes the right hemisphere.
    Trend t-maps across the four working memory conditions based on quantified CBF. p < 0.05 corrected. ‘L’ denotes the left hemisphere of the brain and ‘R’ denotes the right hemisphere.
  • [ Figure 3. ]  The average quantitative CBF values in the TNN and TPN ROIs (A), in the ROIs which exhibited linearly decreasing CBF (B), in the cortical ROIs which exhibited linearly increasing CBF (C), in the subcortical ROIs which exhibited linearly increasing CBF (D), and in the cerebellar ROIs which exhibited linearly increasing CBF (E) from 0b to 3b. Bars labeled in blue, cyan, pink and red demonstrate the CBF values under 0b, 1b, 2b and 3b, separately. TNN: task negative network; TPN: task positive network. PCC: posterior cingulate cortex; MPFC: medial prefrontal cortex; laTEMP: left anterior temporal gyrus; raTEMP: right anterior temporal gyrus. lIPL: left inferior parietal lobule. rIPL: right inferior parietal lobule. lMFG: left middle frontal gyrus; rMFG: right middle frontal gyrus; SMA: supplementary motor area; lpreCG: left precentral cingulate gyrus; ldlPFC: left dorsolateral prefrontal cortex; rdlPFC: right dorsolateral prefrontal cortex; laINS: left anterior insula; raINS: right anterior insula. lCAD: left caudate; rCAD: right CAD; lTHA: left thalamus; rTHA: right thalamus. lCEB/FG: left cerebellum/fusiform gyrus; rCEB/ FG: right cerebellum/fusiform gyrus.
    The average quantitative CBF values in the TNN and TPN ROIs (A), in the ROIs which exhibited linearly decreasing CBF (B), in the cortical ROIs which exhibited linearly increasing CBF (C), in the subcortical ROIs which exhibited linearly increasing CBF (D), and in the cerebellar ROIs which exhibited linearly increasing CBF (E) from 0b to 3b. Bars labeled in blue, cyan, pink and red demonstrate the CBF values under 0b, 1b, 2b and 3b, separately. TNN: task negative network; TPN: task positive network. PCC: posterior cingulate cortex; MPFC: medial prefrontal
cortex; laTEMP: left anterior temporal gyrus; raTEMP: right anterior temporal gyrus. lIPL: left inferior parietal lobule. rIPL: right inferior parietal lobule. lMFG: left middle frontal gyrus; rMFG: right middle frontal gyrus; SMA: supplementary motor area; lpreCG: left precentral cingulate gyrus; ldlPFC: left dorsolateral prefrontal cortex; rdlPFC: right dorsolateral prefrontal cortex; laINS: left anterior insula; raINS: right anterior insula. lCAD: left caudate; rCAD: right CAD; lTHA: left thalamus; rTHA: right thalamus. lCEB/FG: left cerebellum/fusiform gyrus; rCEB/ FG: right cerebellum/fusiform gyrus.
  • [ Figure 4. ]  The average quantitative CBF values in the cortical ROIs exhibiting a quadratic trend of CBF (A) and in the cortical ROIs exhibiting a cubic trend of CBF (B) from 0b to 3b. Bars labeled in blue, cyan, pink and red demonstrate the CBF values under 0b, 1b, 2b and 3b, separately. lIPL: left inferior parietal lobule. rIPL: right inferior parietal lobule.
    The average quantitative CBF values in the cortical ROIs exhibiting a quadratic trend of CBF (A) and in the cortical ROIs exhibiting a cubic trend of CBF (B) from 0b to 3b. Bars labeled in blue, cyan, pink and red demonstrate the CBF values under 0b, 1b, 2b and 3b, separately. lIPL: left inferior parietal lobule. rIPL: right inferior parietal lobule.
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